Christian McCaffrey injury update: 49ers star limited in practice, odds shift in Seahawks’ favor

San Francisco 49ers face uncertainty as star running back Christian McCaffrey appears on the injury report with a calf issue just before the season opener against the Seattle Seahawks. McCaffrey’s injury history raises concerns about his durability, impacting betting markets. While the 49ers have bolstered their backfield depth, his unique skill set remains irreplaceable.