Is Karl-Anthony Towns playing tonight vs Cleveland Cavaliers? Latest update on the New York Knicks star’s injury report (October 22, 2025)

New York Knicks’ star Karl-Anthony Towns is doubtful for tonight’s season opener against the Cavaliers due to a quadriceps strain. Josh Hart and Mitchell Robinson are also out, while OG Anunoby is probable. Towns’ absence significantly impacts the Knicks’ frontcourt, forcing adjustments as they face Cleveland’s formidable interior. The team must adapt to maintain competitiveness early in the season.