Patrick Mahomes pick six leaves Heidi Gardner in disbelief during live ManningCast with Peyton Manning and Eli Manning

Patrick Mahomes threw a crucial interception on October 6, 2025, in Jacksonville. Devin Lloyd returned it 99 yards for a touchdown. This play shifted the game’s momentum. Trevor Lawrence later scored the winning touchdown with seconds remaining. The Jaguars secured a 31-28 victory over the Chiefs. Heidi Gardner’s shocked reaction to the interception went viral online.